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Anticonvulsant use: In convulsive states, dosage of NEMBUTAL Sodium Answer should be kept to some bare minimum in order to avoid compounding the depression which may comply with convulsions. The injection needs to be built slowly and gradually with due regard to some time required to the drug to penetrate the blood-Mind barrier.

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Reports in laboratory animals have revealed that barbiturates bring about reduction while in the tone and contractility in the uterus, ureters, and urinary bladder. Nevertheless, concentrations on the medications necessary to make this outcome in humans aren't attained with sedative-hypnotic doses.

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Untimely infants are notably susceptible to the depressant outcomes of barbiturates. If barbiturates are used during labor and shipping, resuscitation machines really should be available.

Maximal CNS despair might not take place until 15 minutes or more right after IV administration for phenobarbital sodium.

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Barbiturates are metabolized primarily through the hepatic microsomal enzyme technique, as well as metabolic products are excreted inside the urine, and less frequently, while in the feces. Somewhere around twenty five to 50 % of a dose of aprobarbital or phenobarbital is removed unchanged during the urine, Whilst the quantity of other barbiturates excreted unchanged while in the urine is negligible.

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